Short answer; no.
ECWolf and by extension LZWolf are both heavily modified off of the Wolf4SDL engine. As such, other games that heavily modify the source code will usually have features that cannot be correctly mimicked in ECWolf or LZWolf.
However, ECWolf can run mods for Wolfenstein 3D, Spear of Destiny and Super 3D Noah's Ark, as long as they do not require their own custom exe (Such as map packs, sprite replacements, etc).
To do so, do not remove the files from the zip file they came in. Instead, add a blank file called ECWOLF.WL6
(Swap WL6
for the extension of the game the mod is based on) to the zip file. Doing so will make ECWolf treat the zip file like a PK3
when dragged and dropped over the exe.